1. Clinical Study
GLOSSARY
angina chest pain caused by temporary lack of blood supply to an area of heart muscle cells, usually caused by severe obstruction of the artery supplying blood to the segment of cells.
brachial artery the artery of the arm and forearms that supplies blood to the upper limb including the hands.
endothelium the innermost part of the intima that comes in contact with circulating blood, a silky smooth layer of epithelial cells.
ischemia temporary lack of blood and oxygen to an area of cells, for example, the heart muscle, usually due to severe obstruction of the artery supplying blood to this area of cells.

• I. CLINICAL STUDY
  Study question: The many risk factors for coronary artery disease are associated with reduced production of nitric oxide (NO) by the endothelium. L-arginine supplementa¬tion appears to have modest clinical benefits in patients with angina. The effect of a medical food bar containing L-arginine, vitamin B6, B12, vitamin C, folic acid, and niacin was evaluated.
• BIBLIOGRAPHY
  Cannon, R. O. Oral L-arginine (and other active ingredients) for ischemic heart disease? J. Am. Coll. Cardiol., 59:46–47, 2002.

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